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田龙龙(青年研究员)

2021-05-10  兰州大学核科学与技术学院

   

    一、基本情况

        田龙龙,男,1989年06月出生于湖北荆门,现为兰州大学核学院/稀有同位素前沿研究中心,青年研究员。

 

        二、主要学习工作经历

        2022-至今 兰州大学核学院/稀有同位素前沿研究中心

        2019-2021 上海交通大学分子医学研究院博士后,合作导师刘庄教授

        2016-2019 苏州大学功能纳米与软物质研究院化学专业博士研究生,导师刘庄教授

        2015-2016 苏州大学放射医学与防护学院(国家重点实验室)杨凯教授课题组,科研助理

        2012-2015 兰州大学放射化学专业硕士研究生,导师吴王锁教授

        2011-2014 中国科学院近代物理研究所,研究实习员

        2007-2011 兰州大学核化工与核燃料工程专业本科

 

        三、研究领域

        核医学(Nuclear Medicine),放射化学(Radiochemistry),生物医学工程(Biomedical Engineering),肿瘤免疫治疗(Cancer Immunotherapy)。基于小分子、生物大分子(DNA和蛋白质)和纳米生物材料,探索放射性核素在癌症的诊断和治疗中的应用基础研究;探索癌症放射治疗结合新兴的免疫治疗的应用基础研究;探索纳米生物技术用于放射性核素的分离和富集新方法;探索放射性核素的活体分布、监测、代谢和生物效应。

 

        四、主要成果

        个人研究主页:

        https://orcid.org/0000-0002-9343-6561

        https://www.researchgate.net/profile/Longlong-Tian/research

        主持/参与的基金、项目:

        1.  国家自然科学基金青年基金,Na2SX纳米晶体作为新型caspase-9抑制剂用于放射-免疫增效治疗及其机制研究,32101149,30万元,主持;

        2.  获得上海市2019年‘超级博士后’激励计划(青年科技人才)资助(30万/年,2年);上海交通大学医学院博士后激励计划(后备人才)资助;

        3.  中国博士后科学基金,基于临床药物的二维纳米材料推进安全有效的CAR-T细胞治疗的研究,第67批面上项目资助二等,8万元,M2020671143,主持;

        4.  国家自然科学基金,无机纳米反应器与仿生载体用于放射治疗研究,51761145041,199万元,参与;

        5.  国家自然科学基金,肿瘤微环境多指标分子影像方法及其在免疫治疗预后中的应用探索,91959104,80万元,参与;

        6.  国家自然科学基金,基于纳米氧化石墨烯核酸递送系统的大肠癌靶向基因-病毒治疗及其机制研究,81672430,57万元,参与;

        7.  国家自然科学基金,高灵敏度检测脑胶质瘤外泌体中小分子药物代谢的微流控芯片/质谱技术,21874096,66万元,参与;

        授权的专利:

        1.一种共装载化疗药物和放疗药物的蛋白及其应用,已授权,主要完成人。

        2.一种含一氧化氮供体的纳米片及其制备方法与应用,已授权,主要完成人。

        发表的主要论文:

        1. Longlong Tian, Ming Shao, Yimou Gong, Ting Wei, Yujie Zhu, Yu Chao, and Zhuang Liu*, Epigenetic Platinum Complexes Breaking the “Eat Me/Don’t Eat Me” Balance for Enhanced Cancer Chemoimmunotherapy, Bioconjugate Chemistry, 10.1021/acs.bioconjchem.1c00576. (ACS Editors’ Choice)

        2. Longlong Tian, Ming Shao, Yimou Gong, Yu Chao, Ting Wei, Kai Yang, Qian Chen* and Zhuang Liu*, Albumin-binding lipid-aptamer conjugates for cancer immunoimaging and immunotherapy, Science China Chemistry, 10.1007/s11426-021-1168-4.

        3. Longlong Tian, Yujie Zhu, Jun Xu, Ming Shao, Wenjun Zhu, Zhisheng, Xiao, Qian Chen, Zhuang Liu*, Coordination Polymers Integrating Metalloimmunology with Immune Modulation to Elicit Robust Cancer Immunology, CCS Chemistry, 2020, 2, 2629–2642.

        4. Longlong Tian, Yaxing Wang, Lele Sun, Jun Xu, Yu Cao, Kai Yang, Shuao Wang and Zhuang Liu*, 32P-labeled Two-Dimensional ZnFe(CN)5NO with Cerenkov Luminescence Stimulated NO Release for Enhanced Combinational Radioisotope-Immunotherapy, Matter, 2019, 1, 1061-1076.

        5. Longlong Tian, Xuan Yi, Zhiliang Dong, Jun Xu, Liang Chao, Yu Cao, Yaxing Wang, Kai Yang* and Zhuang Liu*, Calcium Bisphosphonate Nanoparticles with Chelator-Free Radiolabeling to Deplete Tumor-Associated Macrophages for Enhanced Cancer Radioisotope Therapy, ACS Nano, 2018, 12, 11541-11551.

        6. Lele Sun#, Fengyun Shen#, Longlong Tian#, Huiquan Tao, Zijian Xiong, Jun Xu, Zhuang Liu*. ATP-Responsive Smart Hydrogel Releasing Immune Adjuvant Synchronized with Repeated Chemotherapy or Radiotherapy to Boost Antitumor Immunity. Advanced Materials, 2021, 2007910.(共一)

        7. Longlong Tian#, Qian Chen#, Xuan Yi, Jiawen Chen, Chao Liang, Yu Chao, Kai Yang,* Zhuang Liu*, Albumin-Templated Manganese Dioxide Nanoparticles for Enhanced Radioisotope Therapy, Small, 2017, 13, 1700640. (共一)

        8. Longlong Tian#, Qian Chen#, Xuan Yi, Guanglin Wang, Jie Chen, Ping Ning, Kai Yang*, Zhuang Liu*, Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-radioisotope Therapy of Cancer, Theranostics, 2017, 7, 614-623. (共一)

        9. Honghong Cao, Wei Qi, Xudong Gao, Qiang Wu, Longlong Tian*, Wangsuo Wu, Graphene Quantum Dots prepared by Electron Beam Irradiation for Safe Fluorescence Imaging of Tumor, Nanotheranostics 2022; 6(2):205-214.

        10.  Longlong Tian#, Liu Dan#, Huang Lingxin, Cao Shiwei, Qi Wei, Lin Jing, Wu Qiang, Li Zhan* and Wu Wangsuo*, One-pot Hydrothermal Synthesis of Carbonaceous Nanocomposites for Efficient Decontamination of Copper, RSC Advances, 2015, 5, 98041-98049. (共一)

        11.  Longlong Tian#, Zhang Xin#, Qi Wei, Liu Dan, Jin Qiang, Lin Jin, Ye Yuanlv, Li Zhan* and Wu Wangsuo*, The adsorption of Water-Soluble Ionic Liquids on Graphene Oxide of Different Oxygen Content, RSC Advances, 2014, 4, 58536-58545. (共一)

        12.   Zhan Li#, Chunmei Wang#, Longlong Tian#, Jing Bai, Huijun Yao*, Yang Zhao, Xin Zhang, Shiwei Cao, Wei Qi, Suomin Wang, Keliang Shi, Youwen Xu, Zhang Mingliang, Bo Liu, Hongdeng Qiu*, Jie Liu, Wangsuo Wu*, Xiaoli Wang and An Wenzhen, An embryo of protocells: The capsule of graphene with selective ion channels, Scientific Reports, 2015, 10258. (共一)

        13.  Yu Chao, Ligeng Xu, Chao Liang, Liangzhu Feng, Jun Xu, Ziliang Dong, Longlong Tian, Xuan Yi, Kai Yang* and Zhuang Liu*, Combined Local Immunostimulatory Radioisotope Therapy and Systemic Immune Checkpoint Blockade Imparts Potent Antitumour Responses, Nature Biomedical Engineering, 2018, 2, 611-621.

        14.  Jingjing Liu, Fang Hu, Min Wu, Longlong Tian, Fei Gong, Xiaoyan Zhong, Muchao Chen, Zhuang Liu*, Bin Liu*, Bioorthogonal Coordination Polymer Nanoparticles with Aggregation-Induced Emission for Deep Tumor-Penetrating Radio- and Radiodynamic Therapy, Advanced Materials, 2021, 33, 2007888.

        15.   Jingjing Liu, Longlong Tian, Rui Zhang, Ziliang Dong, Hairong Wang, Zhuang Liu*. Collagenase Encapsulated pH-Responsive Nanoscale Coordination Polymers for Tumor Microenvironment Modulation and Enhanced Photodynamic Nanomedicine, ACS Applied Materials & Interfaces, 2018, 10, 43493-43052.

        16.   Zhan Li, Longlong Tian, Jianli Liu, Wei Qi, Qiang Wu, Haijing Wang, Mohammad Chand Ali, Wangsuo Wu, and Hongdeng Qiu*, Graphene Oxide/Ag Nanoparticles Cooperated with Simvastatin as a High Sensitive X-Ray Computed Tomography Imaging Agent for Diagnosis of Renal Dysfunctions, Advanced Healthcare Materials, 2017, 6, 1700413.

        17.   Yu Chao, Chao Liang, Yu Yang, Guanglin Wang, Debabrata Maiti, Longlong Tian, Fei Wang, Wei Pan, Song Wu*, Kai Yang*, and Zhuang Liu*. Highly Effective Radioisotope Cancer Therapy with a Non-Therapeutic Isotope Delivered and Sensitized by Nanoscale Coordination Polymers, ACS Nano, 12, 7519-7528.

        18.   Wenjun Zhu, Yu Yang, Qiutong Jin, Yu Chao, Longlong Tian, Jingjing Liu, Ziliang Dong, Zhuang Liu*, Two-dimensional Metal-Organic-Framework as a Unique Theranostic Nano-platform for Nuclear Imaging and Chemo-photodynamic Cancer Therapy, Nano Res., 2018, 12,1307-1312.

        19.   Fei Gong, Liang Cheng*, Nailin Yang, Qiutong Jin, Longlong Tian, Mengyun Wang, Yonggang Li, Zhuang Liu*. Bimetallic Oxide MnMoOX Nanorods for in vivo  Photoacoustic Imaging of GSH and Tumor-Specific Photothermal Therapy, Nano Letters 2018, 18, 6037-6044.

        20.  Wenjun Zhu, Qian Chen*, Qiutong Jin, Yu Chao, Lele Sun, Xiao Han, Jun Xu, Longlong Tian, Jinglei Zhang, Teng Liu and Zhuang Liu*. Sonodynamic therapy with immune modulatable two-dimensional coordination nanosheets for enhanced anti-tumor immunotherapy” Nano Res., 2020, 14, 212-221.

        21.   Fei Gong, Muchao Chen, Nailin Yang, Ziliang Dong, Longlong Tian, Yu Hao, Mingpeng Zhuo, Zhuang Liu, Qian Chen*, Liang Cheng*. Bimetallic Oxide FeWOX Nanosheets as Multifunctional Cascade Bioreactors for Tumor Microenvironment-Modulation and Enhanced Multimodal Cancer Therapy. Adv. Funct. Mater., 2020, 2002753.

        22.   Guangzhi Li, Qifang Lei, Fei Wang, Dashi Deng, Shupeng Wang, Longlong Tian, Wanwan Shen, Yiyun Cheng*, Zhuang Liu* and Song Wu*. Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy of Bladder Cancer. Small, 2019, 15, 1900936.

        五、联系方式

        常年招收核学、化学、生物和医学等方向的研究生和博士后,欢迎联系。

        通讯地址:甘肃省兰州市城关区天水南路222号,理工楼1004

        E-mail:tianll12@lzu.edu.cn

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